Depending on your desired workflow, pitch correction can be applied before or after the Sphere plug-in in the signal chain. In either case, it is recommended to use the mono output "Sphere" plug-in, not the stereo output "Sphere 180" plug-in.
Although in most cases we recommend that the Sphere plug-in comes first in the effects signal chain, excellent results can be achieved with pitch correction placed before Sphere by using a stereo instance. When using Auto-Tune the "pitch reference" should be set to the left channel.
When pitch correction is applied after the Sphere plug-in then a mono instance can be used as is typically done.